Title:Sex Steroid Hormone Effects in Normal and Pathologic Conditions in Lung Physiology
Volume: 12
Issue: 11
Author(s): A. Gonzalez-Arenas and J. Agramonte-Hevia
Affiliation:
Keywords:
Estradiol, estrogen receptor, lung, progesterone, progesterone receptor, ER-α, protein–antibody, colony-stimulating factor, edema
Abstract: Progesterone and estradiol participate in the regulation of many pulmonary functions, for example progesterone
mediates the fall of alveolar carbon dioxide tension observed in the luteal phase of the menstrual cycle and during
pregnancy in humans, when progesterone levels are high. The treatment with estradiol diminishes vasoconstriction and
hypoxia. Progesterone and estradiol in addition to participating in non-pathological functions such as vasodilation and
lung maturation, also have influence on pathologies as asthma, cystic diseases and cancer. Therefore this review will
provide an overview of the action and effects of these hormones in lung, their mechanism of action through their
intracellular receptors and their influence over asthma, cystic lung diseases and cancer.
