Title:A Novel and Facile Synthetic Approach for Tasigna
Volume: 8
Issue: 5
Author(s): Xiaoyan Pan, Wen Lu, Pengfei Li, Fang Wang, Chen Wang, Zhigang Hu and Jie Zhang
Affiliation:
Keywords:
Tasigna, Bcr-Abl kinase inhibitor, Facile synthesis, Cu-catalyzed N-arylation, Condensation, tyrosine kinase, tyrosine kinase, Palladium, Nickel, carbonyl chlorides
Abstract: A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40%).
All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic
purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions,
inexpensive reagents, high yield and simple operation.
