Title:Influence of Usnic Acid and its Derivatives on the Activity of Mammalian Poly(ADP-ribose)polymerase 1 and DNA Polymerase β
Volume: 8
Issue: 5
Author(s): Alexandra Zakharenko, Dmitry Sokolov, Olga Luzina, Maria Sukhanova, Svetlana Khodyreva, Olga Zakharova, Nariman Salakhutdinov and Olga Lavrik
Affiliation:
Keywords:
DNA Polymerase β, PARP1, Poly(ADP-ribose)polymerase, Usnic acid, DNA, enzyme, antifungal, carcinoma, malignant, antitumor
Abstract: The influence of a number of usnic acid derivatives on auto(polyADP-ribosyl)ation catalyzed by PARP1 and
DNA synthesis catalyzed by DNA polymerase β was studied. The derivatives of usnic acid containing aromatic substituents
were shown to be moderate inhibitors of PARP1. The presence of both usnic acid tricyclic structure and aromatic
substituent at any position of the molecule is a key factor for the inhibitory action. In the case of DNA polymerase β, no
relationship between the structure and inhibitory properties has been found with the only exception. Derivatives with
modified ring A showed mild activation of DNA synthesis catalyzed by DNA polymerase β.
