Title:Formulation and In Vivo Hypoglycemic Effect of Glipizide Solid Dispersion
Volume: 9
Issue: 4
Author(s): Gayatri C. Patel, Khusman V. Asodaria, Hetal P. Patel and Dinesh R. Shah
Affiliation:
Keywords:
Solid dispersion, Dissolution profile, Preclinical study
Abstract: The present study was carried out with a view to enhance dissolution rate of poorly water-soluble drug glipizide
(GZ) (BCS class II) using polyethylene glycol (PEG) 6000, PEG 8000 and poloxamer (PXM) 188 as carriers. Solid dispersions
(SDs) were prepared by melting method using different ratios of glipizide to carriers. Phase solubility study was
conducted to evaluate the effect of carrier on aqueous solubility of glipizide. SD was optimized by drug content estimation
and in vitro dissolution study and optimised SD was subjected to bulk characterization, Scanning electron microscopy
(SEM), Fourier transformation infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and X-ray diffraction
study (XRD). Preclinical study was performed in mice to study the decrease in blood glucose level from prepared SD
compared with pure drug. Due to high solubility and drug release, PXM 188 in weight ratio of 1:2 was optimized. Decrease
in blood glucose level in mice from SD was significantly higher (p < 0.05) compared to pure glipizide. Thus, solid
dispersion technique can be successfully used for the improvement of the dissolution profile of GZ.
