Title:The Effects of Ageing on Proliferation Potential, Differentiation Potential and Cell Surface Characterisation of Human Mesenchymal Stem Cells
Volume: 7
Issue: 4
Author(s): Emma Fossett, Wasim S. Khan, Philip Pastides and Adetola B. Adesida
Affiliation:
Keywords:
Ageing, characterisation, differentiation, mesenchymal stem cells, proliferation, regenerative medicine, inner cell mass, embryonic stem, adult stem cells, muscle tissue
Abstract: Mesenchymal stem cells (MSCs) have a great capacity for use in regenerative medicine and other clinical
applications. However, one question creating curiosity of their use, is how they are affected by ageing. As we now live
within an ageing population, the prevalence of age related disorders is increasing, so it is important to investigate how
effectively MSCs from older patients can be expanded and differentiated in vitro before their use in autologous cell
transplantation. This paper will look at how ageing effects proliferation potential, differentiation potential and cell surface
characterisation of human mesenchymal stem cells.
