Abstract
In this work, latest reports about metal toxicity, transport and homeostasis have been thoroughly described and discussed. Although diseases associated with transport and homeostasis abnormalities are those of great interest, still a variety of the phenomena associated with these processes are under debate. In this paper, we try to summarize the newest theses on this topic, presenting contradictory points of view. We focus on toxic and essential metal pathways crossing and try to follow the exact metal binding molecules within the body and provide insight into the transport mechanism. Special attention is given to the mechanism of action of lately investigated metal transporters.
Keywords: Metal homeostasis, toxicity, transport
Current Medicinal Chemistry
Title:Metal Transport and Homeostasis within the Human Body: Toxicity Associated with Transport Abnormalities
Volume: 19 Issue: 17
Author(s): S. Potocki, M. Rowinska-Zyrek, D. Witkowska, M. Pyrkosz, A. Szebesczyk, K. Krzywoszynska and H. Kozlowski
Affiliation:
Keywords: Metal homeostasis, toxicity, transport
Abstract: In this work, latest reports about metal toxicity, transport and homeostasis have been thoroughly described and discussed. Although diseases associated with transport and homeostasis abnormalities are those of great interest, still a variety of the phenomena associated with these processes are under debate. In this paper, we try to summarize the newest theses on this topic, presenting contradictory points of view. We focus on toxic and essential metal pathways crossing and try to follow the exact metal binding molecules within the body and provide insight into the transport mechanism. Special attention is given to the mechanism of action of lately investigated metal transporters.
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Cite this article as:
Potocki S., Rowinska-Zyrek M., Witkowska D., Pyrkosz M., Szebesczyk A., Krzywoszynska K. and Kozlowski H., Metal Transport and Homeostasis within the Human Body: Toxicity Associated with Transport Abnormalities, Current Medicinal Chemistry 2012; 19 (17) . https://dx.doi.org/10.2174/092986712800609698
DOI https://dx.doi.org/10.2174/092986712800609698 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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