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Abstract
Hsp70 is a highly conserved protein that refolds misfolded proteins and has numerous housekeeping functions which regulate apoptosis and other cell activities. Hsp70 consists of a nucleotide binding domain which binds ATP and a substrate binding domain that binds misfolded proteins. The substrate binding domain contains a peptide binding pocket which is covered by a helical lid. In humans, there are three major cytosolic Hsp70 isotypes, Hsp70-8, Hsp70-1 and Hsp70-2. Leukemic and numerous other cancer cells have a greater amount of Hsp70-1 and -2, which help the cancer cells inhibit apoptosis in response to stress. This review summarizes the structure and role of Hsp70 proteins in cancer survival.
Keywords: Heat shock protein, Hsp70, structure, cancer, inhibition, housekeeping functions, apoptosis, substrate binding domain, cancer cells, nucleotide-binding domain (NBD), DnaK, ATPase, ATP-induced high-to-low affinity, phospholipases
Protein & Peptide Letters
Title:Role of Hsp70 in Cancer Growth and Survival
Volume: 19 Issue: 6
Author(s): Marcus P.D. Hatfield and Sandor Lovas
Affiliation:
Keywords: Heat shock protein, Hsp70, structure, cancer, inhibition, housekeeping functions, apoptosis, substrate binding domain, cancer cells, nucleotide-binding domain (NBD), DnaK, ATPase, ATP-induced high-to-low affinity, phospholipases
Abstract: Hsp70 is a highly conserved protein that refolds misfolded proteins and has numerous housekeeping functions which regulate apoptosis and other cell activities. Hsp70 consists of a nucleotide binding domain which binds ATP and a substrate binding domain that binds misfolded proteins. The substrate binding domain contains a peptide binding pocket which is covered by a helical lid. In humans, there are three major cytosolic Hsp70 isotypes, Hsp70-8, Hsp70-1 and Hsp70-2. Leukemic and numerous other cancer cells have a greater amount of Hsp70-1 and -2, which help the cancer cells inhibit apoptosis in response to stress. This review summarizes the structure and role of Hsp70 proteins in cancer survival.
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Cite this article as:
P.D. Hatfield Marcus and Lovas Sandor, Role of Hsp70 in Cancer Growth and Survival, Protein & Peptide Letters 2012; 19 (6) . https://dx.doi.org/10.2174/092986612800493968
DOI https://dx.doi.org/10.2174/092986612800493968 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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