Title:Myocardial Structure and Matrix Metalloproteinases
Volume: 12
Issue: 10
Author(s): C. Aggeli, P. Pietri, I. Felekos, L. Rautopoulos, K. Toutouzas, E. Tsiamis and C. Stefanadis
Affiliation:
Keywords:
Metaloproteinases, myocardial structure, extracellular matrix proteins, prognostic role of MMPs, numerous studies, myocardial remodeling, cardiovascular diseases, clinical and therapeutic implications, left ventricular (LV), cardiac remodeling, cardiomyopathy, clinical and therapeutic implications, cell surface proteins, fibrillar collagens
Abstract: Metalloproteinases (MMPs) are enzymes which enhance proteolysis of extracellular matrix proteins. The
pathophysiologic and prognostic role of MMPs has been demonstrated in numerous studies. The present review covers a
wide a range of topics with regards to MMPs structural and functional properties, as well as their role in myocardial remodeling
in several cardiovascular diseases. Moreover, the clinical and therapeutic implications from their assessment are
highlighted.