Title:Biochemical, Enzymatic and Molecular Properties of Renin/Prorenin Mediated by (Pro)Renin Receptor
Volume: 12
Issue: 1
Author(s): A. H.M. Nurun Nabi and Fumiaki Suzuki
Affiliation:
Keywords:
Decoy peptide, “Hinge non-proteolytic activation, peptide, PCP/Fz pathway, prorenin, (pro)renin receptor, renin, V-H+ATPase, Wnt/, β -catenin pathway
Abstract: (Pro)renin receptor, (P)RR, exhibited its crucial role in the renin angiotensin (RA) system and also in such
organ development as the brain and retina. The binding of (pro)renin to (P)RR mediates the enhanced production of
angiotensin-I, which stimulates the tissue-specific RA system and intracellular signal transduction by activating
mitogen-activated protein kinase (ERK) 1/2 and p38 pathways. These characteristics together develop the organ damage,
especially in diabetes and hypertension. (P)RR acts as an adaptor between Wnt receptors and the vacuolar H+-adenosine
triphosphatase (V-ATPase) complex. (P)RR is expressed on the membrane and intracellularly in the golgi apparatus and
endoplasmic reticulum. ADAM19 and Furin cleavage sites in the (P)RR molecule have been identified. A soluble form of
(P)RR has been detected in the cell culture medium and plasma that can bind renin/prorenin. This review describes recent
topics on (pro)renin receptor research in the context of its biochemical and molecular aspects associated with end-stage
organ damage.
