Title:Angiogenesis and AngiomiRs in Non-Hodgkin´s Lymphomas
Volume: 1
Issue: 1
Author(s): Natalia Morais Borges and Gisele W.B. Colleoni
Affiliation:
Keywords:
Non-Hodgkin’s lymphomas, angiogenesis, miRNA, angiomiR
Abstract: MicroRNAs (miRNAs) are a class of endogenous short non-coding RNAs that control gene expression by acting
on target mRNAs for promoting either their degradation or translational repression. Some of them have involvement
in regulating various aspects of angiogenesis, including proliferation, migration and morphogenesis of endothelial cells,
which are important in cardiovascular development and cancer pathogenesis. The identification of angiomiRs (proangiomiRs
and anti-angiomiRs) as the key to control angiogenesis has opened new paths in the treatment of vascular and
oncology diseases. The study of tumor angiogenesis in non-Hodgkin´s lymphomas (NHL) is an interesting and important
topic. In this mini-review we discuss the relationship between angiogenesis and NHL, main angiomiRs and their role as
regulators of gene expression and as potential candidates for target-specific therapies.
