Abstract
Introduction: Previous studies have shown that HIV infection is related to changes in the immune status of the mucosal surfaces. Such changes may also occur in the genital tract, since patients infected by HIV have the virus in their cervical secretions. Methods: Fragments of the uterine cervix of 29 autopsied women were collected at a university hospital from 1985 to 2008, and were divided in groups with and without AIDS. Image J software was used to measure the cervical epithelium and to count the epithelial cellular layers. Langerhans cells (LCs) and IgG positive cells were respectively immunostained with anti-S100 and anti-IgG. Results: Women with AIDS, when compared with women without AIDS, had thinner cervical epithelium (103.32 vs 116.71 μm), lower number of cellular layers (10.41 vs 13.66 μm), lower mean cell diameter (10.09 vs 11.51 μm), less number of total LCs (11.19 vs 23.08 LCs/mm² ), and higher percentage of IgG positive cells (22.64% vs 16.06%). All these results were significant. Conclusion: AIDS causes alterations in the structure of the cervical epithelium and in its extracellular matrix, leading to alterations in the local and systemic immunity, and triggering signs and opportunistic infections in the uterine cervix in the course of the disease.
Keywords: AIDS, atrophy, epithelium, immunity, uterine cervix, women, tract epithelium, Hematoxylin-eosin, Cellular Layers, cervix
Current HIV Research
Title: The Influence of AIDS on the Morphometric and Immune Status of the Uterine Cervix of Autopsied Patients
Volume: 9 Issue: 8
Author(s): Camila Lourencini Cavellani, Laura Penna Rocha, Simone Cristina da Silva Rosa, Livia Ferreira Oliveira, Humberto Aparecido Faria, Janainna Grazielle Pacheco Olegario, Rosana Rosa Miranda Correa and Vicente de Paula Antunes Teixeira
Affiliation:
Keywords: AIDS, atrophy, epithelium, immunity, uterine cervix, women, tract epithelium, Hematoxylin-eosin, Cellular Layers, cervix
Abstract: Introduction: Previous studies have shown that HIV infection is related to changes in the immune status of the mucosal surfaces. Such changes may also occur in the genital tract, since patients infected by HIV have the virus in their cervical secretions. Methods: Fragments of the uterine cervix of 29 autopsied women were collected at a university hospital from 1985 to 2008, and were divided in groups with and without AIDS. Image J software was used to measure the cervical epithelium and to count the epithelial cellular layers. Langerhans cells (LCs) and IgG positive cells were respectively immunostained with anti-S100 and anti-IgG. Results: Women with AIDS, when compared with women without AIDS, had thinner cervical epithelium (103.32 vs 116.71 μm), lower number of cellular layers (10.41 vs 13.66 μm), lower mean cell diameter (10.09 vs 11.51 μm), less number of total LCs (11.19 vs 23.08 LCs/mm² ), and higher percentage of IgG positive cells (22.64% vs 16.06%). All these results were significant. Conclusion: AIDS causes alterations in the structure of the cervical epithelium and in its extracellular matrix, leading to alterations in the local and systemic immunity, and triggering signs and opportunistic infections in the uterine cervix in the course of the disease.
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Lourencini Cavellani Camila, Penna Rocha Laura, Cristina da Silva Rosa Simone, Ferreira Oliveira Livia, Aparecido Faria Humberto, Grazielle Pacheco Olegario Janainna, Rosa Miranda Correa Rosana and de Paula Antunes Teixeira Vicente, The Influence of AIDS on the Morphometric and Immune Status of the Uterine Cervix of Autopsied Patients, Current HIV Research 2011; 9 (8) . https://dx.doi.org/10.2174/157016211798998745
DOI https://dx.doi.org/10.2174/157016211798998745 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
HIV vaccine development
The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
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