Abstract
HAART treatment has greatly improved life expectancy of HIV-1-infected individuals. Unfortunately, latency still remains the major barrier towards HIV-1 eradication. Efforts to identify viral and host cell proteins involved in latency remain important research areas to win this war against HIV-1. Here, we review the contributions of several factors in the establishment of latently infected cells. In addition, we also raise the possibility that RNA helicases, while playing important roles at almost every step of the HIV-1 replication cycle, could be implicated in the processes governing the establishment of these latent reservoirs.
Keywords: AIDS, HIV-1, integration, latency, Rev, RNA helicases, RNA export, Tat, Viral Genomic, RNA, Viral Genomic RNA
Current HIV Research
Title: Implications of RNA Helicases in HIV-1 Replication: Possible Roles in Latency
Volume: 9 Issue: 8
Author(s): Lara Ajamian and Andrew J. Mouland
Affiliation:
Keywords: AIDS, HIV-1, integration, latency, Rev, RNA helicases, RNA export, Tat, Viral Genomic, RNA, Viral Genomic RNA
Abstract: HAART treatment has greatly improved life expectancy of HIV-1-infected individuals. Unfortunately, latency still remains the major barrier towards HIV-1 eradication. Efforts to identify viral and host cell proteins involved in latency remain important research areas to win this war against HIV-1. Here, we review the contributions of several factors in the establishment of latently infected cells. In addition, we also raise the possibility that RNA helicases, while playing important roles at almost every step of the HIV-1 replication cycle, could be implicated in the processes governing the establishment of these latent reservoirs.
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Cite this article as:
Ajamian Lara and J. Mouland Andrew, Implications of RNA Helicases in HIV-1 Replication: Possible Roles in Latency, Current HIV Research 2011; 9 (8) . https://dx.doi.org/10.2174/157016211798998835
DOI https://dx.doi.org/10.2174/157016211798998835 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
HIV vaccine development
The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
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