Abstract
Iodine is a scarce element in soil that is essential for human beings. It constitutes the basis of thyroid hormones, which are important for mammalian metabolism and development and are indispensable for fetal brain development. Iodine deficiency causes multiple disorders and is still the major cause of endemic cretinism. Comparison of different national cancer statistics led to the supposition that there might be an inverse correlation between iodine intake and cancer prevalence. Asian countries which traditionally have an extremely high iodine intake in daily diet, attributable to seaweed consumption, attract attention by having a lower average cancer incidence rate. Today, based on extensive animal and cell experiments, it has been shown that iodine in form of molecular iodine undoubtedly exerts antitumor effects by inducing apoptosis. Although first analyses were performed with breast cancer cells exclusively, the antitumor effects of molecular iodine were extended by us to a wider range of other tumors, confirming that the antitumor effect is not limited solely to breast cancer.
Keywords: Molecular iodine, iodolactones, malignant cell lines, antiproliferative, apoptotic effects, mitochondria-mediated apoptosis, disruption of the mitochondrial transmembrane potential, Apoptosis-inducing factor, Apoptosis signal-regulating kinase, Mitogen-activated protein kinases, Myeloperoxidase, Pendrin, Thyroid peroxidase, Thioredoxin
Current Chemical Biology
Title: Antiproliferative Effects of Molecular Iodine in Cancers
Volume: 5 Issue: 3
Author(s): Pompilio Elio Torremante and Harald Rosner
Affiliation:
Keywords: Molecular iodine, iodolactones, malignant cell lines, antiproliferative, apoptotic effects, mitochondria-mediated apoptosis, disruption of the mitochondrial transmembrane potential, Apoptosis-inducing factor, Apoptosis signal-regulating kinase, Mitogen-activated protein kinases, Myeloperoxidase, Pendrin, Thyroid peroxidase, Thioredoxin
Abstract: Iodine is a scarce element in soil that is essential for human beings. It constitutes the basis of thyroid hormones, which are important for mammalian metabolism and development and are indispensable for fetal brain development. Iodine deficiency causes multiple disorders and is still the major cause of endemic cretinism. Comparison of different national cancer statistics led to the supposition that there might be an inverse correlation between iodine intake and cancer prevalence. Asian countries which traditionally have an extremely high iodine intake in daily diet, attributable to seaweed consumption, attract attention by having a lower average cancer incidence rate. Today, based on extensive animal and cell experiments, it has been shown that iodine in form of molecular iodine undoubtedly exerts antitumor effects by inducing apoptosis. Although first analyses were performed with breast cancer cells exclusively, the antitumor effects of molecular iodine were extended by us to a wider range of other tumors, confirming that the antitumor effect is not limited solely to breast cancer.
Export Options
About this article
Cite this article as:
Elio Torremante Pompilio and Rosner Harald, Antiproliferative Effects of Molecular Iodine in Cancers, Current Chemical Biology 2011; 5 (3) . https://dx.doi.org/10.2174/2212796811105030168
DOI https://dx.doi.org/10.2174/2212796811105030168 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cucurbitacin B Induces DNA Damage, G2/M Phase Arrest, and Apoptosis Mediated by Reactive Oxygen Species (ROS) in Leukemia K562 Cells
Anti-Cancer Agents in Medicinal Chemistry 6-Chloro-7-methyl-3', 4'-dimethoxyflavone – a Potent Selective COX-2 Inhibitor
Medicinal Chemistry Functional Characteristic of Snake Venom Disintegrins: Potential Therapeutic Implication
Current Pharmaceutical Design Allosteric Modulation of Protease-Activated Receptor Signaling
Mini-Reviews in Medicinal Chemistry Synthesis and Antiproliferative Activity of 2-arylidene 6-(2-aryl-2-oxoethoxy)Benzofuran-3-one Derivatives
Letters in Drug Design & Discovery Molecular Imaging Aided Improvement in Drug Discovery and Development
Current Biotechnology Challenges in Managing Amniotic Fluid Embolism: An Up-to-Date Perspective on Diagnostic Testing with Focus on Novel Biomarkers and Avenues for Future Research
Current Pharmaceutical Biotechnology Antibody Gene Therapy: Getting Closer to Clinical Application?
Current Gene Therapy Angiogenesis and Angiogenesis Inhibitors: a New Potential Anticancer Therapeutic Strategy
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Targeted Drug Delivery to Central Nervous System (CNS) for the Treatment of Neurodegenerative Disorders: Trends and Advances
Central Nervous System Agents in Medicinal Chemistry Episcopic 3D Imaging Methods: Tools for Researching Gene Function
Current Genomics <i>Fagonia indica</i>; A Review on Chemical Constituents, Traditional Uses and Pharmacological Activities
Current Pharmaceutical Design Recent Patents on Live Bacteria and their Products as Potential Anticancer Agents
Recent Patents on Anti-Cancer Drug Discovery Heme Oxygenase-1 as a Target for the Design of Gene and Pharmaceutical Therapies for Autoimmune Diseases
Current Gene Therapy Targeting Toll-like Receptors in Autoimmunity
Current Drug Targets Current and Emerging Therapy for Malignant Pleural Mesothelioma: Focus on CD26/Dipeptidyl Peptidase IV as a Therapeutic Target
Current Cancer Therapy Reviews Recent Developments in Patents Targeting Toll-Like Receptor Genes
Recent Patents on DNA & Gene Sequences Relevance of Nutritional Antioxidants in Metabolic Syndrome, Ageing and Cancer: Potential for Therapeutic Targeting
Infectious Disorders - Drug Targets Posttranscriptional Regulation of p53 and its Targets by RNABinding Proteins
Current Molecular Medicine Enhanced Biocatalytic Activity of Recombinant Lipase Immobilized on Gold Nanoparticles
Current Pharmaceutical Biotechnology