Title: Chlamydia-Secreted Proteins in Chlamydial Interactions with Host Cells
Volume: 5
Issue: 1
Author(s): Guangming Zhong, Lei Lei, Siqi Gong, Chunxie Lu, Manli Qi and Ding Chen
Affiliation:
Keywords:
Chlamydia, effectors, host-pathogen interactions, pathogenesis, secretion, intracellular growth cycle, elementary body, epithelial cell, cytoplasmic vacuole, cytosol, host cell, infection, heparin sulfate-like, glycosaminoglycan, Major Outer Membrane Protein, neutralization, antibodies, multiple ligand, insulin, estrogen receptors, platelet, growth factor, protein disulfate isomerase, T cells, HIV invasion, nonphagocytic, mammalian cells, translocated actin-recruiting phosphoprotein (TARP), scaffold protein, cytoskeleton, endocytic pathway, cytoplasm, parasite acquisition, nutrients, lymphocytes, kinases, phosphorylation, cytotoxin homologues, trachomatis, pneumoniae, heterologous systems, cytokinesis, centrosome, retinoblastoma protein, mitochondrial cytochrome, inflammatory, microinjection, sphingomyelin, cholesterol, Golgi apparatus, lipids, Protochlamydia amoebophila, amoeba's, parasitic replication, chloramphenicol, lumen, Bioinformatics, pathogenesis-relevant, Heterologous Secretion Systems, gram-negative bacteria, Yersinia, hybrid, proteome array, Cell-Fractionation, Gel Resolution, perfringolysin, cytosolic fraction, cell nuclei, fluorescence microscope
Abstract: Chlamydial interactions with host cells rely on chlamydia-secreted proteins, including preexisting and newly synthesized proteins. The preexisting proteins released from EBs participate in both chlamydial entry and intracellular survival at the early stage while the newly synthesized proteins secreted from RBs can both manipulate host cell signaling pathways and promote chlamydial reinfection. Despite the significant progresses made in the past decade, the precise mechanisms on what and how chlamydia-secreted proteins interact with host cells remain largely unknown, and will therefore still represent major research directions of the chlamydial field in the foreseeable future. Development of more effective methodologies will aid in discovery of new secretion molecules and novel mechanisms utilized in chlamydial interactions with host cells. The continuing accumulation of knowledge on chlamydia-secreted proteins and their mechanism of action may lead to discovery of novel prevention and therapeutic reagents for preventing and controlling chlamydial infection and pathologies.
