Title: Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model
Volume: 4
Issue: 3
Author(s): Richard A. Peterson, David L. Krull, H. Roger Brown and Mark de Serres
Affiliation:
Keywords:
Chimeric, drug metabolism, hepatocyte, humanized, liver, mouse
Abstract: Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio® (uPA+/+/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.
