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Abstract
Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio® (uPA+/+/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.
Keywords: Chimeric, drug metabolism, hepatocyte, humanized, liver, mouse
Drug Metabolism Letters
Title: Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model
Volume: 4 Issue: 3
Author(s): Richard A. Peterson, David L. Krull, H. Roger Brown and Mark de Serres
Affiliation:
Keywords: Chimeric, drug metabolism, hepatocyte, humanized, liver, mouse
Abstract: Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio® (uPA+/+/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.
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Cite this article as:
A. Peterson Richard, L. Krull David, Roger Brown H. and de Serres Mark, Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model, Drug Metabolism Letters 2010; 4 (3) . https://dx.doi.org/10.2174/187231210791698456
DOI https://dx.doi.org/10.2174/187231210791698456 |
Print ISSN 1872-3128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-0758 |
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