Title: Synthesis, Characterisation, Anti-Microbial Activity and Docking Studies of Novel Dispiro- Oxindolopyrrolidines
Volume: 3
Issue: 1
Author(s): Adukamparai R. Suresh Babu, Raghavachary Raghunathan, Kuppamuthu Kumaresan and Nanjian Raaman
Affiliation:
Keywords:
1,3-dipole/kwd, >, azomethine ylide, oxindole, pyrrolizidines, antimicrobial activity
Abstract: 2-arylidene-1,3-indanediones undergo a regioselective 1,3-dipolar cycloaddition reaction with the azomethine ylide derived from isatin and proline to give a rare class of novel complex dispirooxindolopyrrolizidines in better yield under microwave irradiation than classical heating. X-ray crystal structure analysis of one of the product confirms the structure and regiochemical outcome of the cycloaddition reaction. Anti-microbial activity studies were carried out with all the newly synthesized dispiro-oxindolopyrrolizidines.
