Abstract
The therapy of systemic lupus erythematosus (SLE), a systemic autoimmune disease of unknown aetiology, is significantly complicated by the diversity of disease manifestations and by a variety of complex immune abnormalities. Recent preclinical studies have shown the therapeutic efficacy of several drugs and/or new compounds, some of which have been tested in clinical trials. This review provides an update on the use of new approaches in SLE and recent patents that could develop into novel therapeutics available to the clinical armamentarium for the management of the disease.
Keywords: Systemic lupus erythematosus, autoimmune disease, immune tolerance, β cells, costimulation, therapy
Recent Patents on Inflammation & Allergy Drug Discovery
Title: New Therapies in SLE
Volume: 2 Issue: 1
Author(s): Antonio La Cava, Francesca Ferrera, Gilberto Filaci, Marta Rizzi, Ram P. Singh, Francesco Indiveri and Bevra H. Hahn
Affiliation:
Keywords: Systemic lupus erythematosus, autoimmune disease, immune tolerance, β cells, costimulation, therapy
Abstract: The therapy of systemic lupus erythematosus (SLE), a systemic autoimmune disease of unknown aetiology, is significantly complicated by the diversity of disease manifestations and by a variety of complex immune abnormalities. Recent preclinical studies have shown the therapeutic efficacy of several drugs and/or new compounds, some of which have been tested in clinical trials. This review provides an update on the use of new approaches in SLE and recent patents that could develop into novel therapeutics available to the clinical armamentarium for the management of the disease.
Export Options
About this article
Cite this article as:
Cava La Antonio, Ferrera Francesca, Filaci Gilberto, Rizzi Marta, Singh P. Ram, Indiveri Francesco and Hahn H. Bevra, New Therapies in SLE, Recent Patents on Inflammation & Allergy Drug Discovery 2008; 2 (1) . https://dx.doi.org/10.2174/187221308783399243
DOI https://dx.doi.org/10.2174/187221308783399243 |
Print ISSN 1872-213X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-2710 |
Related Articles
-
Micronutrients at the Interface Between Inflammation and Infection Ascorbic Acid and Calciferol. Part 2: Calciferol and the Significance of Nutrient Supplements
Inflammation & Allergy - Drug Targets (Discontinued) Therapeutic Blockade of TCR Signal Transduction and Co-Stimulation in Autoimmune Disease
Current Drug Targets - Inflammation & Allergy Fragment-Based Optimization of Small Molecule CXCL12 Inhibitors for Antagonizing the CXCL12/CXCR4 Interaction
Current Topics in Medicinal Chemistry Gene Therapy Targeting Nuclear Factor-κB: Towards Clinical Application in Inflammatory Diseases and Cancer
Current Gene Therapy Diabetes Mellitus: A Potential Target for Stem Cell Therapy
Current Stem Cell Research & Therapy The Study of HLA Class II and Autoimmune Diabetes
Current Molecular Medicine Diagnosis of Systemic Lupus Erythematosus in an Unusual Presentation: What a Primary Care Physician Should Know
Current Rheumatology Reviews Synthesis and Immunosuppressive Activity of New Mycophenolic Acid Derivatives
Medicinal Chemistry Psychoneuroimmunology - Psyche and Autoimmunity
Current Pharmaceutical Design Regulation of the PI3K-Akt Network: Current Status and a Promise for the Treatment of Human Diseases
Current Signal Transduction Therapy Transglutaminases as Targets for Pharmacological Inhibition
Mini-Reviews in Medicinal Chemistry The AKT Axis as a Therapeutic Target in Autoimmune Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets The Role of Transforming Growth Factor-β1 Gene Polymorphism and Its Serum Levels in Hashimoto’s Thyroiditis
Current Pharmaceutical Biotechnology Mouse Models of Autoimmune Diseases
Current Drug Discovery Technologies IL-17 and its Receptor Complex as Therapeutic Targets in Arthritis
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Control of Interleukin-1β Secretion in Inflammation and Immune Response
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents CCR1 Chemokine Receptor Antagonist
Current Pharmaceutical Design Effects of Secondhand Smoke on Thyroid Function
Inflammation & Allergy - Drug Targets (Discontinued) Phospholipid/Bile Salt Based Novel Mixed Nanomicelles of Methotrexate Co-encapsulated with Sesamol: Preparation, Characterization, and Evaluation of Antiradical Effects In Vitro
Current Nanomedicine Somatic Genome Variations in Health and Disease
Current Genomics