Title: The TB Structural Genomics Consortium: Providing a Structural Foundation for Drug Discovery
Volume: 2
Issue: 2
Author(s): J. Shaun Lott, Thomas C. Terwilliger, William Jacobs, Jr., Bernhard Rupp, Tom Alber, James Sacchettini, David Eisenberg, Min S. Park, Vivek Sharma, Joel Berendzen, Andrew W. Munro, Kirsty J. McLean, David Leys, Vickery L. Arcus, Edward N. Baker, Celia W. Goulding, Jodie M. Johnston, Shekhar C. Mande, Nandita Bachhawat, Avinash Kale, Radha Chauhan, Se Won Suh, Geoffrey S. Waldo, Jin KukYang, Mack R. Kuo, Clare V. Smith, Harindarpal S. Gill, Daniel H. Anderson and Marcin Apostol
Affiliation:
Abstract: Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.
