Title: Frequency of CYP1A2 Polymorphism in Beagle Dogs
Volume: 1
Issue: 2
Author(s): Valerie J. Whiterock, Terrye A. Delmonte, Lester E. Hui, Tami L. Orcutt and Michael W. Sinz
Affiliation:
Keywords:
Polymorphism, dog, CYP1A2, frequency, poor metabolizers, pharmacokinetics
Abstract: A single nucleotide polymorphism in the dog CYP1A2 gene causes these animals to be CYP1A2 deficient (i.e., lack functional CYP1A2 enzyme activity). Genotyping a colony of 79 dogs revealed 77% wild-type, 19% heterozygous, and 4% homozygous mutant animals. These genetic frequencies are significantly different from those previously reported and illustrate that different sources and populations of dogs can have dramatically different frequencies of this polymorphism.