Title: Disposition of Vorinostat, A Novel Histone Deacetylase Inhibitor and Anticancer Agent, in Preclinical Species
Volume: 1
Issue: 2
Author(s): Punam Sandhu, Paul A. Andrews, Maribeth P. Baker, Kenneth A. Koeplinger, Eric D. Soli, Thomas Miller and Thomas A. Baillie
Affiliation:
Keywords:
Vorinostat, histone deacetylases, glucuronidation, β-oxidation, 4-anilino-4-oxobutanoic acid
Abstract: The disposition of vorinostat, an anticancer agent, was investigated in rats and dogs. Vorinostat possessed high serum clearance, a short elimination half-life and low oral bioavailability in both species. The renal route played an important role in the elimination of drug-related material and vorinostat was eliminated primarily by metabolic biotransformation.