Abstract
Many therapeutic drugs currently in use are cationic amphiphiles. These cationic amphiphilic drugs (CADs) induce phospholipidosis in humans and experimental animals. The recent study shows that CAD-induced cellular phospholipidosis is linked to the impairment of phospholipid catabolism by inhibition of lysosomal phospholipase A2 activity.
Keywords: Cationic amphiphilic drug, amiodarone, PDMP, tetracycline, phospholipidosis, lysosomal phospholipase A2
Drug Metabolism Letters
Title: A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis
Volume: 1 Issue: 1
Author(s): Akira Abe, Miki Hiraoka and James A. Shayman
Affiliation:
Keywords: Cationic amphiphilic drug, amiodarone, PDMP, tetracycline, phospholipidosis, lysosomal phospholipase A2
Abstract: Many therapeutic drugs currently in use are cationic amphiphiles. These cationic amphiphilic drugs (CADs) induce phospholipidosis in humans and experimental animals. The recent study shows that CAD-induced cellular phospholipidosis is linked to the impairment of phospholipid catabolism by inhibition of lysosomal phospholipase A2 activity.
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Cite this article as:
Abe Akira, Hiraoka Miki and Shayman A. James, A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis, Drug Metabolism Letters 2007; 1 (1) . https://dx.doi.org/10.2174/187231207779814292
DOI https://dx.doi.org/10.2174/187231207779814292 |
Print ISSN 1872-3128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-0758 |
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