Title: A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis
Volume: 1
Issue: 1
Author(s): Akira Abe, Miki Hiraoka and James A. Shayman
Affiliation:
Keywords:
Cationic amphiphilic drug, amiodarone, PDMP, tetracycline, phospholipidosis, lysosomal phospholipase A2
Abstract: Many therapeutic drugs currently in use are cationic amphiphiles. These cationic amphiphilic drugs (CADs) induce phospholipidosis in humans and experimental animals. The recent study shows that CAD-induced cellular phospholipidosis is linked to the impairment of phospholipid catabolism by inhibition of lysosomal phospholipase A2 activity.
