Title: ABCB1, SLCO1B1 and UGT1A1 Gene Polymorphisms Are Associated with Toxicity Line Irinotecan
Volume: 1
Issue: 1
Author(s): Katrin E. Rhodes, Wu Zhang, Dongyun Yang, Oliver A. Press, Michael Gordon, Daniel Vallbohmer, Anne M. Schultheis, Georg Lurje, Robert D. Ladner, William Fazzone, Heinz-Josef Lenz and Syma Iqbal
Affiliation:
Keywords:
Polymorphisms, colorectal cancer, toxicity, irinotecan
Abstract: We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.