Title: Effect of Common NAT2 Variant Alleles in the Acetylation of the Major Clonazepam Metabolite, 7-minoclonazepam
Volume: 1
Issue: 1
Author(s): M. Olivera, C. Martinez, G. Gervasini, J. A. Carrillo, S. Ramos, J. Benitez, E. Garcia-Martin and J. A. G. Agundez
Affiliation:
Keywords:
NAT2, acetylation, polymorphism, pharmacogenomics
Abstract: We investigated the role of NAT2 on clonazepam acetylation, using transiently expressed human NAT2 alleles. The NAT25*B and the NAT2*6A variant alleles cause a 20 and 22-fold reduction in the Vmax, respectively. We conclude that NAT2 is responsible for 7-aminoclonazepam acetylation and that NAT2 gene polymorphisms impair such metabolic pathway.