Title: Herpes Simplex Virus-Induced Ocular Diseases: Detrimental Interaction Between Virus and Host
Volume: 7
Issue: 3
Author(s): Georges M.G.M. Verjans and Arnd Heiligenhaus
Affiliation:
Keywords:
Herpes simplex virus, keratitis, uveitis, epidemiology, clinical symptoms, diagnosis, pathogenesis, treatment, Ocular Diseases, Neurotrophic keratitis, dendritic HSV lesion, Corneal endotheliitis, Stromal keratitis, Acute retinal necrosis
Abstract: Herpes simplex virus type 1 (HSV-1) is a common cause of ocular diseases, affecting all parts of the visual axis. HSV-1 keratitis and uveitis represent two prevalent ocular diseases. The outcome of these potentially sightthreatening conditions depends on prompt diagnosis and treatment in order to counteract the detrimental intra-ocular virus-host interaction. This review recapitulates current insights on the diagnosis, pathogenesis, and treatment of HSV-1 keratitis and uveitis in patients and in the respective mouse models.
