Abstract
This review discusses the most active natural and synthetic curarelike compounds demonstrating myorelaxants activity. The data are grouped according to chemical structures, namely, quinoline and isoquinoline myorelaxants, myorelaxants with saturated heterocyclic or alkylamine fragments, myorelaxants with a steroid framework, natural and synthetic alkaloid myorelaxants.
Keywords: Curarelike compounds, natural and synthetic myorelaxants, nondepolarizing and depolarizing substances, diquarternized myorelaxants, diquar-ternized myorelaxants, Strychnos, Chondodendron, curare alkaloids, relax-ant action, linkers, antitumor, anti-HIV, antimalarial, hypotensive, nondepolarizing substances, depolarizing substances, Isoquinoline Myorelaxants, Tubocurarine, Chondodendron tomentosum, Me-nispermaceae, Atracurium, nerve blockers, succinyl choline, tetrahydroisoquinoline chlo-rofumarates, cis-dibenzoquinolizine chlorofu-marates, piperidine, morpholine, indolenine, alkaloid thesine, central cyclobutane ring, anatruxonium, Diplacin, Qualidyl, alkanedicar-bonyl fragment, antagonists of acetylcholine, depo-larizing myorelaxant dithylinum, Sux-amethonium, Imbretyl, Paramyon, diadonium, decadonium, oligodimethylsi-loxanes
Mini-Reviews in Medicinal Chemistry
Title: Diquaternized Curarelike Myorelaxants: Structure and Biological Activity
Volume: 10 Issue: 13
Author(s): N. F. Salakhutdinov and G. A. Tolstikov
Affiliation:
Keywords: Curarelike compounds, natural and synthetic myorelaxants, nondepolarizing and depolarizing substances, diquarternized myorelaxants, diquar-ternized myorelaxants, Strychnos, Chondodendron, curare alkaloids, relax-ant action, linkers, antitumor, anti-HIV, antimalarial, hypotensive, nondepolarizing substances, depolarizing substances, Isoquinoline Myorelaxants, Tubocurarine, Chondodendron tomentosum, Me-nispermaceae, Atracurium, nerve blockers, succinyl choline, tetrahydroisoquinoline chlo-rofumarates, cis-dibenzoquinolizine chlorofu-marates, piperidine, morpholine, indolenine, alkaloid thesine, central cyclobutane ring, anatruxonium, Diplacin, Qualidyl, alkanedicar-bonyl fragment, antagonists of acetylcholine, depo-larizing myorelaxant dithylinum, Sux-amethonium, Imbretyl, Paramyon, diadonium, decadonium, oligodimethylsi-loxanes
Abstract: This review discusses the most active natural and synthetic curarelike compounds demonstrating myorelaxants activity. The data are grouped according to chemical structures, namely, quinoline and isoquinoline myorelaxants, myorelaxants with saturated heterocyclic or alkylamine fragments, myorelaxants with a steroid framework, natural and synthetic alkaloid myorelaxants.
Export Options
About this article
Cite this article as:
F. Salakhutdinov N. and A. Tolstikov G., Diquaternized Curarelike Myorelaxants: Structure and Biological Activity, Mini-Reviews in Medicinal Chemistry 2010; 10 (13) . https://dx.doi.org/10.2174/13895575110091248
DOI https://dx.doi.org/10.2174/13895575110091248 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Drugs and mitochondria
Mitochondria play a central role in the life and death of cells. They are not merely the center for energy metabolism but are also the headquarters for different catabolic and anabolic processes, calcium fluxes, and various signaling pathways. Mitochondria maintain homeostasis in the cell by interacting with reactive oxygen-nitrogen species ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Transdermal Delivery: Product and Patent Update
Recent Patents on Drug Delivery & Formulation Traumatic Chylothorax due to Cervical Stab Wound: A Case Report
New Emirates Medical Journal A Detailed Review of Various Herbal Treatment Options for Potentially Curing or Ameliorating Pain in Diabetic Neuropathy
Current Traditional Medicine Fibromyalgia Syndrome: Which Antidepressant Drug Should We Choose
Current Pharmaceutical Design 2,5-Diketopiperazines: A Review of Source, Synthesis, Bioactivity, Structure, and MS Fragmentation
Current Medicinal Chemistry Calcium Homeostasis and Kinetics in Heart Failure
Medicinal Chemistry Kinins and Cardiovascular Diseases
Current Pharmaceutical Design The Perfect Storm: A Rheumatologist's Point of View on COVID-19 Infection
Current Rheumatology Reviews The Influence of Genetic Variations and Drug Interactions Based on Metabolism of Antidepressants and Anticonvulsants
Current Drug Metabolism Natural Products; Pharmacological Importance of Family Cucurbitaceae: A Brief Review
Mini-Reviews in Medicinal Chemistry Dose-dependent Effects of Esmolol-epinephrine Combination Therapy in Myocardial Ischemia and Reperfusion Injury
Current Pharmaceutical Design L-Arginine Availability as a Pathological Mechanism in Essential Hypertension, Chronic Renal and Heart Failure
Vascular Disease Prevention (Discontinued) Minoxidil Use in Dermatology, Side Effects and Recent Patents
Recent Patents on Inflammation & Allergy Drug Discovery Daily Melatonin Administration Attenuates Age-Dependent Disturbances of Cardiovascular Rhythms
Current Aging Science Preeclampsia as a Multifactorial Pregnancy Disorder: Clinical Symptoms,Diagnostic Tools and Research Strategies
Current Women`s Health Reviews Management of Hypertension in Relation to Acute Coronary Syndromes and Revascularisation
Current Pharmaceutical Design A Brief Overview on Chemistry and Biology of Benzoxepine
Letters in Drug Design & Discovery Risk Stratification in Pulmonary Embolism
Current Respiratory Medicine Reviews A Review Study about the Effect of Chitosan Nanocarrier on Improving the Efficacy of Amphotericin B in the Treatment of Leishmania from 2010 to 2020
Current Drug Delivery Effects of <i>Nigella Sativa</i> (Black seeds) Supplementation on Plasma Lipid Profile in Human Subjects - A Review
Current Nutraceuticals