Title: Synthesis and Biological Evaluation of Novel Bioisosteric Analogues of Dimebon™
Volume: 7
Issue: 6
Author(s): Alexandre Vasilevich Ivachtchenko, Eugene Borisovich Frolov, Oleg Dmitrievich Mitkin, Sergey Evgenevich Tkachenko and Alexandre Khvat
Affiliation:
Keywords:
Dimebon™, Inhibitor, 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole, Alzheimer's disease, Parallel synthesis, GPCR, Analogues
Abstract: In the present paper, we describe the synthesis and biological evaluation for a series of novel 6,9-disubstituted 2-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indoles. These compounds represent unique bioisosteric analogues of Dimebon ™ with promising biological activity against a panel of various targets including some GPCR family members.
