Abstract
Atherosclerosis is an inflammatory disease characterized by lipid accumulation as well as vascular injury due to a massive infiltration of immune cells in the endothelial wall. Microbial and self- antigens are responsible for a persistent activation of immune and non-immune cells, thus leading to a condition of arterial chronic inflammation with plaque formation and rupture in complicated cases. In particular, the effects of bacteria, viruses and their toxic products as well as of glycated lipoproteins will be illustrated with special reference to the main inflammatory pathways triggered by a persistent antigenic load in the host. Taking into consideration this broad variety of antigens implicated in the pathogenesis of atherosclerosis, therapeutic approaches such as antibiotics, dietary intervention and immune therapies will be discussed.
Keywords: Advanced glycated end products, bacteria, endothelial cells, glycated proteins, heat-shock proteins, immune cells, lipopolysaccharides, toll-like receptors
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: A Broad Variety of Antigens Contribute to the Pathogenesis of Atherosclerosis: How to Neutralize Noxious Reactions in the Host
Volume: 10 Issue: 2
Author(s): T. Magrone and E. Jirillo
Affiliation:
Keywords: Advanced glycated end products, bacteria, endothelial cells, glycated proteins, heat-shock proteins, immune cells, lipopolysaccharides, toll-like receptors
Abstract: Atherosclerosis is an inflammatory disease characterized by lipid accumulation as well as vascular injury due to a massive infiltration of immune cells in the endothelial wall. Microbial and self- antigens are responsible for a persistent activation of immune and non-immune cells, thus leading to a condition of arterial chronic inflammation with plaque formation and rupture in complicated cases. In particular, the effects of bacteria, viruses and their toxic products as well as of glycated lipoproteins will be illustrated with special reference to the main inflammatory pathways triggered by a persistent antigenic load in the host. Taking into consideration this broad variety of antigens implicated in the pathogenesis of atherosclerosis, therapeutic approaches such as antibiotics, dietary intervention and immune therapies will be discussed.
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Magrone T. and Jirillo E., A Broad Variety of Antigens Contribute to the Pathogenesis of Atherosclerosis: How to Neutralize Noxious Reactions in the Host, Endocrine, Metabolic & Immune Disorders - Drug Targets 2010; 10 (2) . https://dx.doi.org/10.2174/187153010791213083
DOI https://dx.doi.org/10.2174/187153010791213083 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
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