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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

A Storage Protein-Like Trypsin Inhibitor from the Moth Bean (Phaseolus acutifolius) with Antiproliferative Activity Toward Lymphoma Cells

Author(s): D.Z. Ma, J. Sun, G.Q. Zhang, H.X. Wang and T.B. Ng

Volume 17, Issue 6, 2010

Page: [782 - 788] Pages: 7

DOI: 10.2174/092986610791190408

Price: $65


A 26-kDa trypsin inhibitor with an N-terminal sequence resembling storage proteins was purified from moth beans (Phaseolus acutifolius). It dose-dependently inhibited trypsin with an IC50 value of about 0.38 μM. It inhibited [methyl-3H] thymidine incorporation by lymphoma MBL2 cells with an IC50 value of 20 μM.

Keywords: antiproliferative, lymphoma cells, moth bean, purification, storage protein, trypsin inhibitor

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