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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity

Author(s): Juliana I. dos Santos, Carlos A.H. Fernandes, Angelo J. Magro and Marcos R.M. Fontes

Volume 16, Issue 8, 2009

Page: [887 - 893] Pages: 7

DOI: 10.2174/092986609788923310

Price: $65

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Abstract

Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity.

Keywords: Phospholipase A2 homologues, snake venom, oligomeric conformation, quaternary structure, myotoxicity, X-ray crystallography


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