![conference banner](/images/conference-banner.jpeg)
Abstract
Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity.
Keywords: Phospholipase A2 homologues, snake venom, oligomeric conformation, quaternary structure, myotoxicity, X-ray crystallography
Protein & Peptide Letters
Title: The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity
Volume: 16 Issue: 8
Author(s): Juliana I. dos Santos, Carlos A.H. Fernandes, Angelo J. Magro and Marcos R.M. Fontes
Affiliation:
Keywords: Phospholipase A2 homologues, snake venom, oligomeric conformation, quaternary structure, myotoxicity, X-ray crystallography
Abstract: Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity.
Export Options
About this article
Cite this article as:
dos Santos I. Juliana, Fernandes A.H. Carlos, Magro J. Angelo and Fontes R.M. Marcos, The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity, Protein & Peptide Letters 2009; 16 (8) . https://dx.doi.org/10.2174/092986609788923310
DOI https://dx.doi.org/10.2174/092986609788923310 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Apixaban: A New Player in the Anticoagulant Class
Current Drug Targets Antidote Control of Aptamer Therapeutics: The Road to a Safer Class of Drug Agents
Current Pharmaceutical Biotechnology Secondary Hypertension: The Ways of Management
Current Vascular Pharmacology Approaching Neurological Diseases to Reduce Mobility Limitations in Older Persons
Current Pharmaceutical Design Genomics of Addiction
Current Psychiatry Reviews Safety of Spinal Anesthesia in a Patient with Achondroplasia for Cesarean Section
Current Drug Safety A Novel Therapeutic Strategy Against Vascular Disorders with Chymase Inhibitor
Current Vascular Pharmacology Non Peptidic Urotensin II Antagonists: Perspectives for a New Class of Drugs
Cardiovascular & Hematological Agents in Medicinal Chemistry Structure-Function Relationships of PEDF
Current Molecular Medicine Current Therapeutic Drugs Against Cerebral Vasospasm after Subarachnoid Hemorrhage: A Comprehensive Review of Basic and Clinical Studies
Current Drug Delivery Synthesis and Bioactivity of (R)-Ricinoleic Acid Derivatives: A Review
Current Medicinal Chemistry Effect of Grapefruit Juice in Relation to Human Pharmacokinetic Study
Current Clinical Pharmacology Postoperative Care of the Transplanted Patient
Current Cardiology Reviews Sepsis, Coagulation and Anticoagulants
Endocrine, Metabolic & Immune Disorders - Drug Targets Update of Targeted Therapy-Induced Hypertension: Basics for Non-Oncology Providers
Current Hypertension Reviews Development and Validation of a UPLC-MS/MS Method for the Simultaneous Determination of Verapamil and Trandolapril in Rat Plasma: Application to a Pharmacokinetic Study
Current Pharmaceutical Analysis Off-Pump Coronary Artery Bypass Grafting; is it Still Relevant?
Current Cardiology Reviews Fatal Lactic Acidosis Precipitated by Nifedipine in a Patient Treated with Disulfiram and Antiretrovirals
Drug Metabolism Letters The Impact of Hypertension in Hemodialysis Patients
Current Hypertension Reviews Usefulness of Magnetic Resonance Imaging in Cardiac and Enovascular Intervention
Current Medical Imaging