![conference banner](/images/conference-banner.jpeg)
Abstract
Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.
Keywords: Membrane permeabilization, molecular mechanism, micelle nucleation
Protein & Peptide Letters
Title: Calcium-Independent Membrane Damage by Venom Phospholipases A2
Volume: 16 Issue: 8
Author(s): A.H.C. de Oliveira, E. A. Aragao, J. M. Sa, L. Chioato, R. Bugs-Bortoleto, R. Ruller, T. L. Ferreira and R. J. Ward
Affiliation:
Keywords: Membrane permeabilization, molecular mechanism, micelle nucleation
Abstract: Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.
Export Options
About this article
Cite this article as:
de Oliveira A.H.C., Aragao A. E., Sa M. J., Chioato L., Bugs-Bortoleto R., Ruller R., Ferreira L. T. and Ward J. R., Calcium-Independent Membrane Damage by Venom Phospholipases A2, Protein & Peptide Letters 2009; 16 (8) . https://dx.doi.org/10.2174/092986609788923392
DOI https://dx.doi.org/10.2174/092986609788923392 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cellular Mechanisms of Brain Injury and Cell Death
Current Pharmaceutical Design Nitric Oxide: Cancer Target or Anticancer Agent?
Current Cancer Drug Targets Neuroleptics and Migraine
Central Nervous System Agents in Medicinal Chemistry Management of Patients with Heart Failure: Focus on New Pharmaceutical and Device Options
Current Medicinal Chemistry Pathophysiology of Sepsis and Recent Patents on the Diagnosis, Treatment and Prophylaxis for Sepsis
Recent Patents on Inflammation & Allergy Drug Discovery Possible Role of Vascular Risk Factors in Alzheimer's Disease and Vascular Dementia
Current Pharmaceutical Design Binary Actin-ADP-Ribosylating Toxins and their Use as Molecular Trojan Horses for Drug Delivery into Eukaryotic Cells
Current Medicinal Chemistry The Role of Atypical Antipsychotic Agents in the Treatment of Schizophrenia and Schizoaffective Disorders in the Elderly
Current Drug Safety Natural Products Based Ayurvedic Formulations: Chemical Cons tituents and Treatment in Neurodegenerative Disordersǂ
Mini-Reviews in Organic Chemistry Neurokinin-1 Receptor (NK-1R) Antagonists: Potential Targets in the Treatment of Glioblastoma Multiforme
Current Medicinal Chemistry The Role of Protease-Activated Receptors for the Development of Myocarditis: Possible Therapeutic Implications
Current Pharmaceutical Design Non-ambient Conditions in the Investigation and Manufacturing of Drug Forms
Current Pharmaceutical Design Pharmacological and Biological Activities of Xanthones
Anti-Infective Agents in Medicinal Chemistry Dipeptidyl Peptidase-4 Inhibition: Linking Chemical Properties to Clinical Safety
Current Medicinal Chemistry Vitamin E-Related Inhibition of Monocyte 5-Lipoxygenase and Cardiovascular Outcome in Maintenance Hemodialysis Patients
Recent Patents on Inflammation & Allergy Drug Discovery Heart Failure in Minority Populations - Impediments to Optimal Treatment in Australian Aborigines
Current Cardiology Reviews Antiatherosclerotic and Cardioprotective Effects of Time-Released Garlic Powder Pills
Current Pharmaceutical Design Current Drug Targets and Future Therapy of Pulmonary Arterial Hypertension
Current Medicinal Chemistry Multi-component Reactions for the Synthesis of Biologically Relevant Molecules Under Environmentally Benign Conditions
Current Organic Chemistry New Targets for Treating the Underlying Pathophysiology and Nonmotor Aspects of Parkinson's Disease
CNS & Neurological Disorders - Drug Targets