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Abstract
Surfactant dysfunction has been demonstrated in clinical and experimental studies of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Inflammatory mediators, alveolar exudation, capillary endotheliopathy, and various other mechanisms have been indicted as the cause of surfactant dysfunction. In addition, loss of biophysical activity and damage to the type II alveolar cells leads to altered surfactant production, secretion, and recycling. These factors provide the conceptual rationale for administering exogenous surfactant in ALI/ARDS. Studies of surfactant replacement therapy in ALI/ARDS in children have shown improvement in various parameters of pulmonary function. Multiple simultaneous interventions in the treatment of ALI/ARDS have improved survival and outcomes. The objective of this review is to address the current literature and evidence supporting the administration of exogenous surfactant in the treatment of children with ARDS/ALI.
Keywords: ALI, ARDS, pediatric, surfactant replacement
Current Respiratory Medicine Reviews
Title: Surfactant Replacement Therapy in Pediatric Acute Lung Injury/Acute Respiratory Distress Syndrome
Volume: 5 Issue: 3
Author(s): Rahul Bhatia, Timothy J. Cox and James H. Hertzog
Affiliation:
Keywords: ALI, ARDS, pediatric, surfactant replacement
Abstract: Surfactant dysfunction has been demonstrated in clinical and experimental studies of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Inflammatory mediators, alveolar exudation, capillary endotheliopathy, and various other mechanisms have been indicted as the cause of surfactant dysfunction. In addition, loss of biophysical activity and damage to the type II alveolar cells leads to altered surfactant production, secretion, and recycling. These factors provide the conceptual rationale for administering exogenous surfactant in ALI/ARDS. Studies of surfactant replacement therapy in ALI/ARDS in children have shown improvement in various parameters of pulmonary function. Multiple simultaneous interventions in the treatment of ALI/ARDS have improved survival and outcomes. The objective of this review is to address the current literature and evidence supporting the administration of exogenous surfactant in the treatment of children with ARDS/ALI.
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Cite this article as:
Bhatia Rahul, Cox J. Timothy and Hertzog H. James, Surfactant Replacement Therapy in Pediatric Acute Lung Injury/Acute Respiratory Distress Syndrome, Current Respiratory Medicine Reviews 2009; 5 (3) . https://dx.doi.org/10.2174/157339809788922324
DOI https://dx.doi.org/10.2174/157339809788922324 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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Chronic obstructive pulmonary disease (COPD) from childhood to adulthood: from the past to the future
Chronic obstructive pulmonary disease (COPD) is one of the three leading causes of death worldwide, with a major prevalence in low- and middle-income countries, resulting in a high social and economic cost. It is a heterogeneous respiratory disease, treatable and preventable, that causes persistent and often progressive airway obstruction in ...read more
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