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Abstract
The acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are part of a devastating syndrome characterized by acute onset, hypoxemia, and bilateral infiltrates on chest X-rays. ALI/ARDS arises from the lungs response to local or systemic aggression in which local inflammation and coagulation disorders lead to increased inflammatory pulmonary edema. ARDS is a major cause of morbidity, death, and cost in intensive care units. ALI and ARDS are associated with increased procoagulant and reduced fibrinolytic activities mainly in alveoli and interstitial spaces. Fibrin deposition, which is the hallmark of early phase ALI, stimulates fibroblast aggregation and collagen secretion, contributing to pulmonary fibrosis. The only clinical intervention that has a significant impact on mortality in ARDS is the use of low tidal volume ventilation. ARDS has many coagulation disorders in common with severe sepsis, where recombinant human activated protein C has reduced mortality, hastened improvement in respiratory dysfunction, and shortened the duration of mechanical ventilation. Future clinical trials in ALI/ARDS should evaluate the potential benefits of anticoagulants administered systemically or locally in the lungs.
Keywords: Acute respiratory distress syndrome, acute lung injury, coagulation disorders, activated protein C
Current Respiratory Medicine Reviews
Title: Coagulation Disorders in Acute Lung Injury
Volume: 5 Issue: 3
Author(s): Melanie Adda, Ricard Ferrer, Ferranda Puig, Javier Crespo and Antoni Artigas
Affiliation:
Keywords: Acute respiratory distress syndrome, acute lung injury, coagulation disorders, activated protein C
Abstract: The acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are part of a devastating syndrome characterized by acute onset, hypoxemia, and bilateral infiltrates on chest X-rays. ALI/ARDS arises from the lungs response to local or systemic aggression in which local inflammation and coagulation disorders lead to increased inflammatory pulmonary edema. ARDS is a major cause of morbidity, death, and cost in intensive care units. ALI and ARDS are associated with increased procoagulant and reduced fibrinolytic activities mainly in alveoli and interstitial spaces. Fibrin deposition, which is the hallmark of early phase ALI, stimulates fibroblast aggregation and collagen secretion, contributing to pulmonary fibrosis. The only clinical intervention that has a significant impact on mortality in ARDS is the use of low tidal volume ventilation. ARDS has many coagulation disorders in common with severe sepsis, where recombinant human activated protein C has reduced mortality, hastened improvement in respiratory dysfunction, and shortened the duration of mechanical ventilation. Future clinical trials in ALI/ARDS should evaluate the potential benefits of anticoagulants administered systemically or locally in the lungs.
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Adda Melanie, Ferrer Ricard, Puig Ferranda, Crespo Javier and Artigas Antoni, Coagulation Disorders in Acute Lung Injury, Current Respiratory Medicine Reviews 2009; 5 (3) . https://dx.doi.org/10.2174/157339809788922342
DOI https://dx.doi.org/10.2174/157339809788922342 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Chronic obstructive pulmonary disease (COPD) from childhood to adulthood: from the past to the future
Chronic obstructive pulmonary disease (COPD) is one of the three leading causes of death worldwide, with a major prevalence in low- and middle-income countries, resulting in a high social and economic cost. It is a heterogeneous respiratory disease, treatable and preventable, that causes persistent and often progressive airway obstruction in ...read more
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