Title: Natural and Synthetic Compounds with an Antimycobacterial Activity
Volume: 6
Issue: 2
Author(s): L. N. Rogoza, N. F. Salakhutdinov and G. A. Tolstikov
Affiliation:
Keywords:
Tuberculosis, multidrug-resistance tuberculosis, M. tuberculosis, antimycobacterial activity, antituberculosis activity, cytotoxicity, “structure-activity” relationships
Abstract: This review discusses the most active natural and synthetic compounds demonstrating the antimycobacterial activity at minimum inhibiting concentrations (MIC) of 5 μg/ml or less. For better insight into the “structure-activity” relationships, we occasionally considered compounds with high values of MIC. The review covers the period from 2001 to 2007. The data are grouped according to chemical structures, namely, nitrogen-, oxygen-, and sulfur-containing heterocyclic compounds, peptide, alkaloids, terpenoids, and others.