Title: Proteomic Identification of a Monoclonal Antibody Recognizing Caveolin-1 in Hepatocellular Carcinoma with Metastatic Potential
Volume: 16
Issue: 5
Author(s): Mei-yu Hu, Chi-tat Lam, Kang-da Liu, Zhi Xu, Sarwat Fatima, Yvonne C.F Su, Felice Tsang, Jie Chen, Jin-zhong Pang, Lun-xiu Qin and J. M. Luk
Affiliation:
Keywords:
Hepatocellular carcinoma, caveolin-1, monoclonal antibody, metastasis
Abstract: A monoclonal antibody, McAb9E (IgG3), was generated against a metastatic HCC cell line, MHCC-1. The antigen was characterized as human Caveolin-1 (Cav-1, 21kDa), with pI of 5.65. The Cav-1 antigen was found significantly over expressed in metastatic HCC cell lines as well as in tumor specimens. The Cav-1 specific McAb may be a useful molecular agent for metastatic HCC.