Title: Monitoring the Pharmacokinetics of Pyridinium Aldoximes in the Body
Volume: 9
Issue: 5
Author(s): H. Kalasz, J. Furesz and K. Tekes
Affiliation:
Keywords:
Pyridinium aldoximes, pralidoxime, K-27, K-48, K-203
Abstract: A huge number of organophosphate poisonings occurring in agriculture, and a constant threat of misapplication of organophosphates as warfare agents require antidotes that efficiently improve the health-condition of intoxicated subjects. Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates. This paper outlines pharmacokinetics, metabolic disposition and blood-brain-barrier penetration of pyridinium aldoximes into the human and animal body, and the methods of their pharmacological analysis.