Abstract
State-of-the-art biochemistry methods in combination with an automated phenotyping method demonstrate the high potential of transgenic tobacco plants in producing properly-folded therapeutic proteins for the treatment of protein-misfolding diseases (e.g., Alzheimers disease). This molecular farming approach led to highest protein production of hydroponically- grown tobacco compared to other growth substrates generally used in plant cultivation.
Keywords: Protein folding, Alzheimer's disease, molecular farming, PMPs, value-added biochemicals, methodologial strategy
Protein & Peptide Letters
Title: Novel Detection System for Plant Protein Production of Pharmaceuticals and Impact on Conformational Diseases
Volume: 17 Issue: 6
Author(s): Kerstin A. Nagel, Bernd Kastenholz, Frank Gilmer, Ulrich Schurr and Achim Walter
Affiliation:
Keywords: Protein folding, Alzheimer's disease, molecular farming, PMPs, value-added biochemicals, methodologial strategy
Abstract: State-of-the-art biochemistry methods in combination with an automated phenotyping method demonstrate the high potential of transgenic tobacco plants in producing properly-folded therapeutic proteins for the treatment of protein-misfolding diseases (e.g., Alzheimers disease). This molecular farming approach led to highest protein production of hydroponically- grown tobacco compared to other growth substrates generally used in plant cultivation.
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Cite this article as:
A. Nagel Kerstin, Kastenholz Bernd, Gilmer Frank, Schurr Ulrich and Walter Achim, Novel Detection System for Plant Protein Production of Pharmaceuticals and Impact on Conformational Diseases, Protein & Peptide Letters 2010; 17 (6) . https://dx.doi.org/10.2174/092986610791190282
DOI https://dx.doi.org/10.2174/092986610791190282 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
Call for Papers in Thematic Issues
Therapeutic Proteins and Peptides of Plant Origin
Plants are still the major repository of biologically active substances. In the last two decades, however, natural peptides and proteins of plant origin have gained increasing attention due to their pharmacological activities over a variety of human illness, including those mediated by infections and parasitosis and those involving different cellular ...read more
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