Title: Epigenetic Regulation and Therapeutic Approaches in Cancer
Volume: 8
Issue: 15
Author(s): Felix Recillas-Targa
Affiliation:
Keywords:
Epigenetics, genetics, chromatin, chromatin remodelling, DNA methylation, cancer, inhibitors, therapies
Abstract: The interdependency between genetic and epigenetic regulatory processes renders cancer therapeutics and translational clinic possible, even though they remain difficult tasks considering all the evidence supporting a central role of progenitor-stem cells as a causative source of cellular transformation. In contrast to genetic alterations, epigenetic processes are potentially reversible allowing a better action of complementary therapeutic compounds. Here I would first describe the plethora of interconnected epigenetic processes and targets to then discuss several therapeutic strategies on the basis of different compounds. I conclude that the advent of new and specific epigenetic target drugs will certainly contribute to better treatments and to the development of predictive protocols in a next future.
