Title: Apoptosis in Atherosclerosis: A Mini-Review
Volume: 8
Issue: 9
Author(s): Maria Karaflou, Irene Lambrinoudaki and George Christodoulakos
Affiliation:
Keywords:
Atherosclerosis, apoptosis, pathogenesis
Abstract: Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.