Abstract
Predictive medicine is a new philosophy in healthcare and an attractive subject for currently initiated research activities aimed at a potential application of innovative biotechnologies in the prediction of human pathologies, a development of well-timed prevention and individual therapy-planning. Diabetes care is one of the best examples of an absolute necessity for well-timed prediction, prevention and personalized treatment. Diabetes mellitus frequently results in diverse severe complications, such as retinopathy, nephropathy, silent ischemia, dementia, and cancer – the cascade of chronic complications appearing as “domino-effect”. Promising approaches of differential plasma proteome, detection of circulating nucleic acids and gene expression profiling in circulating leukocytes are currently discussed for development of potent diagnostic, prognostic and therapeutic targets. Minimal invasive insulin administration approaches and/or improvement of pancreatic activity in own insulin production is the main goal of novel drug delivery systems highly desirable for advanced treatment of diabetic patients with both type 1 and type 2 of the disease. High potential of an application of novel gene therapy approaches in diabetes care is expected for such advanced technologies as gene repair by gene replacement therapies.
Keywords: Metabolic syndrome, advanced technologies, novel targets, early / predictive diagnosis, drug delivery, gene therapy
Infectious Disorders - Drug Targets
Title: Diabetes Care: Risk Factors, Prediction, Prevention, and Individualized Treatment
Volume: 8 Issue: 2
Author(s): Olga Golubnitschaja
Affiliation:
Keywords: Metabolic syndrome, advanced technologies, novel targets, early / predictive diagnosis, drug delivery, gene therapy
Abstract: Predictive medicine is a new philosophy in healthcare and an attractive subject for currently initiated research activities aimed at a potential application of innovative biotechnologies in the prediction of human pathologies, a development of well-timed prevention and individual therapy-planning. Diabetes care is one of the best examples of an absolute necessity for well-timed prediction, prevention and personalized treatment. Diabetes mellitus frequently results in diverse severe complications, such as retinopathy, nephropathy, silent ischemia, dementia, and cancer – the cascade of chronic complications appearing as “domino-effect”. Promising approaches of differential plasma proteome, detection of circulating nucleic acids and gene expression profiling in circulating leukocytes are currently discussed for development of potent diagnostic, prognostic and therapeutic targets. Minimal invasive insulin administration approaches and/or improvement of pancreatic activity in own insulin production is the main goal of novel drug delivery systems highly desirable for advanced treatment of diabetic patients with both type 1 and type 2 of the disease. High potential of an application of novel gene therapy approaches in diabetes care is expected for such advanced technologies as gene repair by gene replacement therapies.
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Cite this article as:
Golubnitschaja Olga, Diabetes Care: Risk Factors, Prediction, Prevention, and Individualized Treatment, Infectious Disorders - Drug Targets 2008; 8 (2) . https://dx.doi.org/10.2174/187152608784746538
DOI https://dx.doi.org/10.2174/187152608784746538 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
Call for Papers in Thematic Issues
New Frontiers in Infectious Disease Research: Small-Molecule Probes and Biomarker Identification
The biological relevance of small-molecule chemical probes targeting a disease model is crucial in the early stages of drug discovery. The integration of omics technologies such as genomics, proteomics, metabolomics, immunomic, and cellular levels has greatly enhanced the ability to identify novel biomarkers and understand the complex interactions between pathogens ...read more
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