Title: Importance of Iron and Iron Metabolism in Nonalcoholic Fatty Liver Disease
Volume: 8
Issue: 2
Author(s): Nahum Mendez-Sanchez, Hector Baptista-Gonzalez, Norberto C. Chavez-Tapia, Daniel Zamora-Valdes and Misael Uribe
Affiliation:
Keywords:
Iron, iron overload, insulin resistance, metabolic syndrome, nonalcoholic fatty liver disease
Abstract: Iron homeostasis disturbances are associated with liver disease. Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease, which can progress to hepatic cirrhosis and end-stage liver disease. Increasing information supports that multiple factors underlie the development and progression of nonalcoholic steatohepatitis. However, the relation between non-alcoholic steatohepatitis and iron metabolism/ overload is still controversial. We review the recent literature, both basic and clinical, regarding iron homeostasis as it pertains to the pathogenesis of nonalcoholic fatty liver disease.
