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Abstract
Bombesin-like peptides (BLP) and its receptors are widely distributed in mammalian peripheral tissues and in the central nervous system. Recently, effects of these peptides on the production and release of cytokines were described both in animal models and humans with inflammatory diseases. Some pathological conditions such as exposure to tobacco smoke, chronic obstructive pulmonary diseases and eosinophilic granuloma have recently been found to be associated with an increase of pulmonary BLP-producing cells. Proinflammatory neuropeptides have a key role in the pathogenesis and maintenance of rheumatoid arthritis and sepsis. Together, these findings support the view that the GRPR should be considered a therapeutic target for a subset of inflammatory diseases.
Keywords: Neuropeptide, bombesin-like peptides, gastrin-releasing peptide receptor, immune system, sepsis
Inflammation & Allergy - Drug Targets (Discontinued)
Title: Gastrin-Releasing Peptide Receptor as a Molecular Target for Inflammatory Diseases
Volume: 6 Issue: 4
Author(s): Felipe Dal Pizzol, Fabricia Petronilho, Rafael Roesler and Gilberto Schwartsmann
Affiliation:
Keywords: Neuropeptide, bombesin-like peptides, gastrin-releasing peptide receptor, immune system, sepsis
Abstract: Bombesin-like peptides (BLP) and its receptors are widely distributed in mammalian peripheral tissues and in the central nervous system. Recently, effects of these peptides on the production and release of cytokines were described both in animal models and humans with inflammatory diseases. Some pathological conditions such as exposure to tobacco smoke, chronic obstructive pulmonary diseases and eosinophilic granuloma have recently been found to be associated with an increase of pulmonary BLP-producing cells. Proinflammatory neuropeptides have a key role in the pathogenesis and maintenance of rheumatoid arthritis and sepsis. Together, these findings support the view that the GRPR should be considered a therapeutic target for a subset of inflammatory diseases.
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Cite this article as:
Pizzol Dal Felipe, Petronilho Fabricia, Roesler Rafael and Schwartsmann Gilberto, Gastrin-Releasing Peptide Receptor as a Molecular Target for Inflammatory Diseases, Inflammation & Allergy - Drug Targets (Discontinued) 2007; 6 (4) . https://dx.doi.org/10.2174/187152807783334319
DOI https://dx.doi.org/10.2174/187152807783334319 |
Print ISSN 1871-5281 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4055 |
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