Abstract
During the past years a number of potent and selective antagonists for the human A3 adenosine receptor (AR) have been developed, including tricyclic compounds, such as triazoloquinazoline, pyrazolo-triazolopyridine, imidazopurinone, triazoloquinoxaline and pyrazoloquinoline derivatives. Bicyclic compounds include isoquinoline and related quinazoline derivatives. Monocyclic dihydropyridine and pyridine derivatives also proved to be potent selective A3 AR antagonists. So far, no potent, selective antagonist is available for rodent A3 ARs. Most of the A3 AR antagonists are highly lipophilic and exhibit very poor water-solubility. Potential therapeutic applications for A3 AR antagonists include inflammatory diseases, asthma, stroke, and glaucoma.
Keywords: Adenosine Receptor Antagonists, Imidazo purin-5-ones, Xanthines, Triazoloquinazolines, Pyrazolo-triazolo-pyrimidines, Pyrrolo pyrimidines (7-deazaade-nines), 1,4-Dihydropyridines, Pyridines, Pyrans, Flavonoids
Mini-Reviews in Medicinal Chemistry
Title: A3 Adenosine Receptor Antagonists
Volume: 1 Issue: 4
Author(s): C. E. Muller
Affiliation:
Keywords: Adenosine Receptor Antagonists, Imidazo purin-5-ones, Xanthines, Triazoloquinazolines, Pyrazolo-triazolo-pyrimidines, Pyrrolo pyrimidines (7-deazaade-nines), 1,4-Dihydropyridines, Pyridines, Pyrans, Flavonoids
Abstract: During the past years a number of potent and selective antagonists for the human A3 adenosine receptor (AR) have been developed, including tricyclic compounds, such as triazoloquinazoline, pyrazolo-triazolopyridine, imidazopurinone, triazoloquinoxaline and pyrazoloquinoline derivatives. Bicyclic compounds include isoquinoline and related quinazoline derivatives. Monocyclic dihydropyridine and pyridine derivatives also proved to be potent selective A3 AR antagonists. So far, no potent, selective antagonist is available for rodent A3 ARs. Most of the A3 AR antagonists are highly lipophilic and exhibit very poor water-solubility. Potential therapeutic applications for A3 AR antagonists include inflammatory diseases, asthma, stroke, and glaucoma.
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Cite this article as:
Muller E. C., A3 Adenosine Receptor Antagonists, Mini-Reviews in Medicinal Chemistry 2001; 1 (4) . https://dx.doi.org/10.2174/1389557510101040417
DOI https://dx.doi.org/10.2174/1389557510101040417 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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