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Abstract
Lipopolysaccharide (LPS) induced Gram-negative sepsis and septic shock remain lethal in up to 60 percent of cases, and LPS antagonists that neutralize its endotoxic action are the subject of intensive research. In the last decade peptidic antagonists have become increasingly important in providing leads for treatment of LPS-mediated diseases. In this review an overview of the sources, functions and structures of antiseptic and antibacterial peptides that interact with LPS is presented.
Keywords: Lipopolysaccharide, Lipopeptides Polymyxin, Lactoferrin Lactoferricin, Polymyxin B
Mini-Reviews in Medicinal Chemistry
Title: Peptides Neutralizing Lipopolysaccharide - Structure and Function
Volume: 1 Issue: 4
Author(s): P. Pristovsek and J. Kidric
Affiliation:
Keywords: Lipopolysaccharide, Lipopeptides Polymyxin, Lactoferrin Lactoferricin, Polymyxin B
Abstract: Lipopolysaccharide (LPS) induced Gram-negative sepsis and septic shock remain lethal in up to 60 percent of cases, and LPS antagonists that neutralize its endotoxic action are the subject of intensive research. In the last decade peptidic antagonists have become increasingly important in providing leads for treatment of LPS-mediated diseases. In this review an overview of the sources, functions and structures of antiseptic and antibacterial peptides that interact with LPS is presented.
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Cite this article as:
Pristovsek P. and Kidric J., Peptides Neutralizing Lipopolysaccharide - Structure and Function, Mini-Reviews in Medicinal Chemistry 2001; 1 (4) . https://dx.doi.org/10.2174/1389557013406729
DOI https://dx.doi.org/10.2174/1389557013406729 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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