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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Syntheses of Cholecystokin in (Cck) Fragment Analogues (26-33) and Comparative Effect on Decreased Feeding in Rats by Cck Fragment (26-33)

Author(s): T. Abiko and S. Nakatsubo

Volume 8, Issue 2, 2001

Page: [153 - 158] Pages: 6

DOI: 10.2174/0929866013409652

Price: $65

Abstract

The peptide analogues of cholecystokinin (CCK) fragment 26-33 in which phenylalanine residue at the 33th position are replaced by phenylglycine [Phg], 1-naphthylalanine [1-Nal], 4-fluorophenylalanine [Phe(4F)], cyclohexylalanine [cHex] and O-methyltyrosine [Tyr(Me)], were synthesized by a solid-phase method and the feeding significance of the aromatic amino acid of this position was comparatively investigated. The in vivo comparative effect on the decreased feeding in rats by peripherally CCK-8 was tested. The observed activities of these peptides were in order [Phe(4F)33]CCK-8) > .[1-Nal33]CCK-8 > CCK-8 > [Tyr(Me)33]CCK-8 > [Phe33]CCK-8. However, the one analogue, [cHex33]CCK-8, had no inhibitory effect on food intake in rats.

Keywords: cholecystokin cck, cck, cholecystokinin cck


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