Title: New Hydrogen Donor: A Facile Method for the Removal of Hydrogenolysable Protecting Groups in Peptide Synthesis.
Volume: 9
Issue: 3
Author(s): D. Channe Gowda and B. Mahesh
Affiliation:
Keywords:
catalytic transfer hydrogenation, hydrazinium monoformate, new hydrogen donor, deprotection
Abstract: Removal of some commonly used protecting groups in peptide synthesis by catalytic transfer hydrogenation employing hydrazinium monoformate and 10%Pd on carbon is described. This method is equally competitive with other methods in deblocking most of the commonly used protecting groups in peptide synthesis. tert-Butyl derived and base labile protecting groups were completely stable under these conditions. This is more effective than hydrazine or formic acid.
