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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Malaria: New Chemotherapeutic Peroxide Drugs

Author(s): Kristina Borstnik, Ik-hyeon Paik and Gary H. Posner

Volume 2, Issue 6, 2002

Page: [573 - 583] Pages: 11

DOI: 10.2174/1389557023405620

Price: $65

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Abstract

Chemical insights into artemisinins biological mechanism of action have allowed rational design of some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarizes recent achievements in this area of peroxide drug development for malaria chemotherapy.

Keywords: malaria, chemotherapeutic peroxide drugs, artemisinin biological mechanism, malaria chemotherapy, antimalarial peroxide artemisinin, anopheline mosquitoes, host bloodstream, aggregation, acute encephalopathy


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