Title: Tubulin as an Antiprotozoal Drug Target
Volume: 2
Issue: 6
Author(s): Karl A. Werbovetz
Affiliation:
Keywords:
tubulin, antiprotozoal drug target, anticancer, anthellmintic, drug-mammalian tubulin interactions, antiparasitic drug candidates, microtubules, protozoan parasites, taxol-site agents, photoaffinity labeling experiments
Abstract: Since tubulin is a known anticancer and anthelmintic drug target, the investigation of protozoal tubulin could lead to the development of new antiparasitic drugs. This review outlines the current state of knowledge concerning drug-mammalian tubulin interactions, the effects of antimicrotubule agents on parasites and parasite tubulin, and our current hypotheses regarding the development of selective ligands for protozoal tubulin as antiparasitic drug candidates.