Abstract
Novel approaches to protein measurement based on mass spectrometry are being developed that challenge more traditional methods. This review summarizes the emergence of mass spectrometry as a tool for clinical protein, peptide, and amino acid determination. Specific applications of mass spectrometry to the measurement of transferrin, transthyretin, glycated hemoglobin, and homocysteine will be discussed, as will the limitations of the technology, and future directions for clinical protein measurement.
Keywords: mass spectrometry, transferrin, transthyretin, glycated hemoglobin, homocysteine, electrospray ionization-mass spectrometry (esims), matrix-assisted laser desorption ionization-mass spectrometry(maldi-ms), glycovariants, serum transferrin, transthyretin variants
Current Protein & Peptide Science
Title: Mass Spectrometry: An Emerging Alternative to Traditional Methods for Measurement of Diagnostic Proteins, Peptides and Amino Acids
Volume: 3 Issue: 2
Author(s): Joseph J. Dalluge
Affiliation:
Keywords: mass spectrometry, transferrin, transthyretin, glycated hemoglobin, homocysteine, electrospray ionization-mass spectrometry (esims), matrix-assisted laser desorption ionization-mass spectrometry(maldi-ms), glycovariants, serum transferrin, transthyretin variants
Abstract: Novel approaches to protein measurement based on mass spectrometry are being developed that challenge more traditional methods. This review summarizes the emergence of mass spectrometry as a tool for clinical protein, peptide, and amino acid determination. Specific applications of mass spectrometry to the measurement of transferrin, transthyretin, glycated hemoglobin, and homocysteine will be discussed, as will the limitations of the technology, and future directions for clinical protein measurement.
Export Options
About this article
Cite this article as:
Dalluge J. Joseph, Mass Spectrometry: An Emerging Alternative to Traditional Methods for Measurement of Diagnostic Proteins, Peptides and Amino Acids, Current Protein & Peptide Science 2002; 3 (2) . https://dx.doi.org/10.2174/1389203024605377
DOI https://dx.doi.org/10.2174/1389203024605377 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Artificial Intelligence for Protein Research
Protein research, essential for understanding biological processes and creating therapeutics, faces challenges due to the intricate nature of protein structures and functions. Traditional methods are limited in exploring the vast protein sequence space efficiently. Artificial intelligence (AI) and machine learning (ML) offer promising solutions by improving predictions and speeding up ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?
Current Vascular Pharmacology Emerging Role of JNK in Insulin Resistance
Current Diabetes Reviews The Promotional Effect of Mesenchymal Stem Cell Homing on Bone Tissue Regeneration
Current Stem Cell Research & Therapy Diabetes Gene Therapy: Potential and Challenges
Current Gene Therapy Insulin Resistance in Type 2 Diabetes - Role of the Adipokines
Current Molecular Medicine Risk Factors for Hyperemesis Gravidarum
Current Women`s Health Reviews The Battle of the Sexes for Stroke Therapy: Female- Versus Male-Derived Stem Cells
CNS & Neurological Disorders - Drug Targets Obesity and Diabetes Gene Discovery Approaches
Current Pharmaceutical Design Diagnostic and Prognostic Markers in Differentiated Thyroid Cancer
Current Genomics Current Therapeutics, Their Problems and Thiol Metabolism as Potential Drug Targets in Leishmaniasis
Current Drug Metabolism A Mendelian Randomization Study on Infant Length and Type 2 Diabetes Mellitus Risk
Current Gene Therapy Protective Effects of Melatonin and Mitochondria-targeted Antioxidants Against Oxidative Stress: A Review
Current Medicinal Chemistry Arterial Wall Structure and Dynamics in Type 2 Diabetes Mellitus Methodological Aspects and Pathophysiological Findings
Current Diabetes Reviews Chemistry in the Bioactivity of Chlorophylls: An Overview
Current Medicinal Chemistry Type 1 Diabetes Treatments Based on Stem Cells
Current Diabetes Reviews Vasopressin in Health and Disease with a Focus on Affective Disorders
Central Nervous System Agents in Medicinal Chemistry Pulmonary Pathology Among Patients with Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-analysis
Current Diabetes Reviews Incretin Based Therapy in the Management of Steroid Induced Diabetes Mellitus
Current Diabetes Reviews Impact and Therapeutic Potential of PPARs in Alzheimers Disease
Current Neuropharmacology Neuro-toxic and Reproductive Effects of BPA
Current Neuropharmacology