Mass Spectrometry: An Emerging Alternative to Traditional Methods for Measurement of Diagnostic Proteins, Peptides and Amino Acids

Joseph   J.   Dalluge

doi:10.2174/1389203024605377

Abstract

Novel approaches to protein measurement based on mass spectrometry are being developed that challenge more traditional methods. This review summarizes the emergence of mass spectrometry as a tool for clinical protein, peptide, and amino acid determination. Specific applications of mass spectrometry to the measurement of transferrin, transthyretin, glycated hemoglobin, and homocysteine will be discussed, as will the limitations of the technology, and future directions for clinical protein measurement.

Keywords: mass spectrometry, transferrin, transthyretin, glycated hemoglobin, homocysteine, electrospray ionization-mass spectrometry (esims), matrix-assisted laser desorption ionization-mass spectrometry(maldi-ms), glycovariants, serum transferrin, transthyretin variants