A Simple Parameter Relating Sequences with Folding Rates of Small α Helical Proteins

Title: A Simple Parameter Relating Sequences with Folding Rates of Small α Helical Proteins

Volume: 10 Issue: 3

Author(s): Hui Shao, Yi Peng and Zong-Hao Zeng

Affiliation:

Keywords: helical proteins, helix parameter, non-polar residues, two-state helical proteins

Abstract: It is found that the helix parameter (HP), which favors clustering of non-polar residues, is linearly correlated with the logarithms of rate constants of folding of small two-state α-helical proteins. The definition is HP = NH-1 Σ [fi+ (fi-1+fi+1) / 2], where fi=1 or -1, if the ith residue is hydrophobic or hydrophilic, respectively, NH is the number of hydrophobic residues and the summation is taken over the hydrophobic residues.

Cite this article as:

Shao Hui, Peng Yi and Zeng Zong-Hao, A Simple Parameter Relating Sequences with Folding Rates of Small α Helical Proteins, Protein & Peptide Letters 2003; 10 (3) . https://dx.doi.org/10.2174/0929866033478906