Title: 7-Keto-Δ5-Steroids: Key-Molecules Owning Particular Biological and Chemical Interest
Volume: 3
Issue: 6
Author(s): E. S. Arsenou, M. A. Fousteris, A. I. Koutsourea and S. S. Nikolaropoulos
Affiliation:
Keywords:
7-keto-, allylic oxidation, 7-keto-cholesterol, 7-keto-dhea, anticancer activity, aromatase inhibitors, apoptosis
Abstract: 7-keto-Δ5-steroids have been suggested for the treatment of several diseases. Their significant biological profile resulted in the development of a great number of methods and reagents for the allylic oxidation of Δ5-steroids. These methods and the biological evaluation of the main oxidized Δ5-steroids are summarized.